Inhibitory effect of Allium sativum and Zingiber officinale extracts on clinically important drug resistant pathogenic bacteria

Inhibitory effect of Allium sativum and Zingiber officinale extracts on clinically important drug resistant pathogenic bacteria

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Abstract Background Herbs and spices are very important and useful as therapeutic agent against many pathological infections.Increasing multidrug resistance of pathogens forces to find alternative compounds for treatment opi the color that keeps on giving of infectious diseases.Methods In the present study the antimicrobial potency of garlic and ginger has been investigated against eight local clinical bacterial isolates.Three types of extracts of each garlic and ginger including aqueous extract, methanol extract and ethanol extract had been assayed separately against drug resistant Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumoniae, Shigella sonnei, Staphylococcusepidermidis and Salmonella typhi.The antibacterial activity was determined by disc diffusion method.

Results All tested bacterial strains were most susceptible to the garlic aqueous extract and showed poor susceptibility to the ginger aqueous extract.The (minimum inhibitory concentration) MIC of different bacterial species varied from 0.05 mg/ml to 1.0 mg/ml.Conclusion In the light of several socioeconomic factors of Pakistan mainly poverty and poor hygienic condition, present study encourages the use of spices as alternative or supplementary medicine to reduce the burden of high cost, sukin body lotion woolworths side effects and progressively increasing drug resistance of pathogens.